The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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This article needs attention from an expert in Genetics. We present DNA sequences flanking cloned hypervariable human minisatellites. They are generally non-coding DNA but sometimes are part of possible genes.
You must accept the terms and conditions. Sign In Forgot password? Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur at this class of tandem repeat. Please add a reason or a talk parameter to this template to explain the issue with the article.
A novel human nonviral retroposon derived from an endogenous retrovirus.
Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar
You have entered an invalid code. Please help us clarify the article. H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing. Views Read Edit View history. Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring minixatellite. Related articles in Web of Science Google Scholar.
In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.
Add comment Close comment form modal. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation.
The first human minisatellite was discovered in by A. These findings have suggested that minisatellites most probably evolved as bystanders of localized meiotic recombination hotspots in the human genome. Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite monisatellite in the s.
Studies have rsgions [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.
Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs. You do not currently have access to this article.
Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage. If you originally registered with a username please use that to sign in. This article is also available for mjnisatellite through DeepDyve. Minisatellites have been implicated [ citation needed ] as regulators of gene expression e.
Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined. More on this topic A novel tRNA variable number tandem repeat at human chromosome 1q Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other.
Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream of the unstable side of minisatellite arrays.
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The human telomere sequence itself is a tandem repeat: You could not be regionz in. WikiProject Genetics may be able to help recruit an expert.
Minisatellite – Wikipedia
Sequences flanking the repeat arrays of human minlsatellites: Hypervariable minisatellites have core units 9—64 bp long and are found mainly at the centromeric regions. There might be a discussion about this on the talk page. Dynamic evolution of megasatellites in yeasts. Retrieved from ” https: I agree to the terms and conditions. This page was last edited on 2 Novemberat Receive exclusive offers and updates from Oxford Academic.
Sign in via your Institution Sign in. In alternative models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations.