DOXIL PI PDF

PI & CMI Trade Names and Active Ingredients containing doxorubicin. 7 Documents available Doxorubicin Ebewe, PI, Doxorubicin hydrochloride. Doxorubicin. Doxil official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Find information on drug affordability programs for DOXIL® (doxorubicin HCl liposome injection). Learn how patients who have been.

In addition, if liposomal doxorubicin escapes from the vein in which it is being administered, it can cause damage to tissues it comes in contact with.

Laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. Patients should ask their physician for recommended products for this use. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug.

And no previous Grade 3 or 4 stomatitis: Manage confirmed or suspected extravasation as follows:. The mechanism of action of doxorubicin HCl is thought to be related to its ability to bind DNA and inhibit nucleic acid synthesis.

Doxil is indicated for the treatment of patients with ovarian cancer whose disease has progressed or recurred after platinum-based chemotherapy. Independent co-pay assistance foundations Independent co-pay assistance foundations have their own rules for eligibility.

What is the mechanism of action?

Doxil was studied in three open-label, single-arm, clinical studies of patients with metastatic ovarian cancer Trials 1, 2, and 3. Doxi doctor will monitor your blood laboratory results. In animal reproduction studies, Doxil was embryotoxic in rats and abortifacient in rabbits following intravenous administration during organogenesis at doses approximately 0. Advise females and males of reproductive potential to use effective contraception during and for 6 months following treatment with Doxil [see Use in Specific Populations 8.

In a pooled analysis of Trials 1—3, the response rate for all patients refractory to paclitaxel and platinum agents was The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This foundation provides financial assistance to those eligible for co-pays and travel costs associated with treatment.

Advise patients to contact their healthcare provider for a new onset fever or symptoms of infection. Also, docil may want to talk to their physician if they are considering having children in the future, since some drugs may cause fertility problems.

Based on findings in animals, Doxil can cause fetal harm when administered to a pregnant woman. The following additional adverse reactions have been identified during post approval use of Doxil. This may lead to tingling or burning, redness, flaking, bothersome swelling, small blisters, or small sores on palms of hands or soles of feet. In certain cases, this reaction can be more severe leading to ppi infections, interfering with walking and other daily activities.

IMPORTANT SAFETY INFORMATION

And no previous Grade 3 or 4 HFS: Reduce Dkxil for serum bilirubin of 1. Because many drugs, including anthracyclines, are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Doxil, discontinue breastfeeding during treatment with Doxil. These malignancies were diagnosed both during treatment with Doxil and up to doixl years after the last dose. Those who are eligible for LIS may: Efficacy results are as shown in Table 13 and Figure 1.

Your doctor will monitor your blood laboratory results. The median number of cycles in each treatment arm was 5 range 1— Discontinue Doxil if HFS is severe and debilitating.

The majority of infusion-related events occurred during the first infusion. Advise females and males of reproductive potential that Doxil may cause temporary or permanent infertility [see Use in Specific Populations 8. By clicking Subscribe, I agree to doxi, Drugs. Cell structure studies have demonstrated rapid cell penetration and perinuclear chromatin binding, rapid inhibition of mitotic activity and nucleic acid synthesis, doxol induction of mutagenesis and chromosomal aberrations.

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers.

In certain cases, this reaction can be more severe leading to serious infections, interfering with walking and other daily activities. doxl

Los Angeles Cancer Network Doxil® – Los Angeles Cancer Network

The possible adverse effects on fertility in animals have not been adequately evaluated. Painless ulcers, erythema, or mild soreness If no previous Grade 3 or 4 toxicity: Although patients will be closely monitored for a reaction, patients should tell their healthcare provider immediately if they are experiencing difficulty breathing, swelling of facial features, back pain, fever, chills, redness of face, tightness of chest, swelling of throat, headache, lightheadedness, dizziness, itching, rash, or noticeable changes in heart rate.

It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA.

Visit this program site HOPE info cancercare. Doxorubicinol, the major metabolite of doxorubicin, was detected at concentrations of 0.