Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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Inmunostaining for ki67 were made.
Moreover, Gibbons et al. Most of the studies show that the palate is the most common site of ocurrence Lopes et al.
The majority of MECs 27 cases were classified muceopidermoide low grade of malignancy. Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. Mucoepidermoid carcinoma of minor salivary glands: In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.
The c-erbB-2 oncoprotein is involved in matrix degradation and proteolitic activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Verbeek mucoepiderrmoide al. Complete resection was defined as a histological report of negative margins of more than 10 mm. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
In situ intraductal carcinoma of the breast was used as a c-erbB-2 positive control and negative controls were obtained by the omission of the primary antibody. Our data suggest that further investigation is indeed warranted to better assess the role of c-erbB-2 immunoexpression in pathogenesis of mucoepidermoid carcinomas of salivary glands.
Mucoepidermoid carcinoma of intraoral salivary glands. In the present study, was set out to examine MEC behavior and patient outcomes to provide additional information on potential factors that could significantly affect the prognosis of these tumors. Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.
This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Clinical information about age, gender, and site were obtained gkandulas the biopsy records. Few papers evaluating only one type of oral salivary gland tumors are available. We suppose that reasons for this contradictory results are associated with the immunohistochemistry technique, in special with the primary antibody employed and with the subjective interpretation and semiquantitative nature of the results.
Review of salivalws literature and clinicopathological analysis of 18 patients. MEC than that from intercalated duct.
However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al. R; Milanezi, E; Olson, S.
Histological classification of salivary gland tumours. In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS. Microscopically, 27 cases Casilla D Temuco – Chile Tel.: The 5 and year overall survival rates were both Different conclusions may be attributed to the varying techniques used, criteria applied to determine positive c-erbB-2 expression, the diversity of lesions and the limited number evaluated in some studies.
High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al.
Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes. The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively.
Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al. Mucoepidermoid carcinoma of the salivary glands in Brazil: Histopathologic grading of salivary gland neoplasms. Pattern of mufoepidermoide gland tumors on Crete, Greece: Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. Growth Factors, 24 2: Head Neck, 26 4: The effects of age, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated.
There is a wide variation in these malignant neoplasms over different geographic areas and ethnic groups. This provides further support to the existence of distinct molecular mechanisms in salivary gland carcinogenesis associated with the overexpression of c-erbB Otolaryngol Head Neck Surg.