Although different methods for the synthesis of Biginelli’s products were based on the use of strong protic .. Pyrimidine and its derivatives. A Mini Review: Biginelli Reaction for the Synthesis of Dihydropyrimidinones. Conference Pyrimidine Containing Derivatives Scheme 7. At the present time there are a few general methods of the synthesis of 5-acyl-1,2, 3,4-tetrahydropyrimidinethiones/ones. One of them is the Biginelli reaction.
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The reaction mixture was allowed to cool and poured on crushed ice. Rapid screening of the antimicrobial activity of extracts and natural products. Each concentration was repeated 4 times for each of the bacteria and the average results of inhibitory effects are illustrated in Table 1.
Regarding the importance of the Biginelli reaction products, much work on improving the yield and reaction conditions has been actively pursued. We biginelil the action of hydrazine hydrate as N -nucleophile on Biginelli pyrimidine esters 4a — 4h. To receive news and publication updates for Journal of Chemistry, enter your email address in the box below.
The latter reaction gave three products, none of them being the expected hydrazide 11a — 11h. Compounds with pyrimidine scaffolds exhibit wide range of diverse pharmacological actions [ 12 pyrimiine and biological activities [ 3 ] such as anti-HIV agent Stavudine [ 4 ], antibiotic Fervennuline [ 5 ], antihypertensive drug Minoxidil [ 6 ], and antibacterial drug Sulfamethazine [ 7 ].
The previous conclusions encouraged us to suppose a mechanism for ring opening of DHPMs by hydrazine hydrate Figure 3. Compounds 2 and 8 showed considerable inhibitory activity against P.
Open in a separate window. Culture was carried out with sterile swab and microtube suspension was cultured for 24 h and then inoculated onto Mueller Hinton agar. A mixture of an ethyl benzoylacetate 1 mmolaromatic aldehyde 1 mmolthiourea 1 mmol and an amount of concentration Hydrochloric acid or DABCO 0.
A New Synthesis of Biginelli Compounds
Correspondence should be addressed to Hazem A. To examine the antibacterial activity of some synthesized compounds, three gram negative bacteria: Recently, we reported a unique behavior of hydrazine hydrate towards certain benzofurans to produce phenolic-based pyrazoles [ 42 ].
Kabil5 Nasser S. Abstract Certain Biginelli pyrimidines with ester substitution in C5 were subjected to bigineelli ring opening upon solvent-free reaction with hydrazine hydrate to give three products: The reaction of C5 esters with thiosemicarbazide, in acetone, to afford thiosemicarbazones 6 is reported Figure 1 [ 39 ].
After reaction completion, the reaction mass was cooled and treated with crushed ice. Basic 3-substitutedaryl-1,4-dihydropyrimidinecarboxylic acid esters. Pyrimidines of Biginelli type 3,4-dihydropyrimidines, DHPMs showed a broad spectrum of biological activities such as anticancer agent, Monastrol Figure 1 [ 89 ]. Al-shakliah3,6 and Hatem A. The Biginelli reaction is a multiple-component chemical reaction that creates 3,4-dihydropyrimidin-2 1 H -ones 4 from ethyl acetoacetate 1an aryl aldehyde such as benzaldehyde 2and urea 3.
Cephalexin was used as the standard antibacterial agent. Except for compound 8, the other compounds did not show any inhibitory activity against E. Tetrahydropyrimidine, antimicrobial activity, Biginelli reaction.
Eldehna2 Hazem A. The solvent control was included, although no antibacterial activity has been noted. Melting points were determined with an Electrothermal digital apparatus and were uncorrected.
MIC value was defined as lowest concentration of compound for inhibition growth of the tested bacteria. Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular.